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AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Gene Name: | basic leucine zipper transcription factor, ATF-like 3 |
Synonyms: | BATF3, JUNDM1, JDP1, Jun dimerization protein 1, B-ATF-3, SNFT |
Target Sequences: | NM_018664 NP_061134.1 Q9NR55 |
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