BAP1

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

BAP1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human BAP1 Protein (Recombinant GST) (Full Length) - LS-G31104

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human BAP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67746

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.2 kDa

Price:

20 µg/$1,107

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Human BAP1 Protein (Recombinant GST, N-terminus) (aa61-160) - LS-G60685

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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BAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100360

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.2 kDa

Price:

100 µg/$494

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Human BAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80618

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.2 kDa

Price:

20 µg/$150

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