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United States
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest.
Gene Name: | BTG3 associated nuclear protein |
Synonyms: | BANP, BEND1, SMARBP1, SMAR1, Protein BANP |
Target Sequences: | NM_017869 NP_060339.2 Q8N9N5 |
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