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BAFF / TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.

Gene Name: tumor necrosis factor (ligand) superfamily, member 13b
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20
Target Sequences: NM_006573 NP_006564.1 Q9Y275

Publications (3)

1
SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis. Eri Itotagawa, Yoshihiko Tomofuji, Yasuhiro Kato, Hachiro Konaka, Kohei Tsujimoto, JeongHoon Park, Daiki Nagira, Takehiro Hirayama, Tatsunori Jo, Toru Hirano, Takayoshi Morita, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Yukinori Okada, Hyota Takamatsu, Atsushi Kumanogoh. Rheumatology (Oxford, England). 2023 May;62:1988-1997. [Full Text Article] [PubMed:36094336] [PMC:PMC10152287] Related Antibodies: LS-B2081.
2
Elevated serum BAFF levels in patients with sarcoidosis: association with disease activity. Ueda-Hayakawa I, Tanimura H, Osawa M, Iwasaka H, Ohe S, Yamazaki F, Mizuno K, Okamoto H. Rheumatology (Oxford, England). 2013 Sep;52:1658-66. [Full Text Article] [PubMed:23685362] Related Antibodies: LS-B2375.
3
B Lymphocyte Stimulator (BLyS) is expressed in human adipocytes in vivo and is related to obesity but not to insulin resistance. M[Character fc]ller N, Schulte DM, Hillebrand S, T[Character fc]rk K, Hampe J, Schafmayer C, Brosch M, von Sch[Character f6]nfels W, Ahrens M, Zeuner R, Schr[Character f6]der JO, Bl[Character fc]her M, Gutschow C, Freitag-Wolf S, Stelmach-Mardas M, Saggau C, Schreiber S, Laudes M. PloS one. 2014 9:e94282. [Full Text Article] [PubMed:24728308] [PMC:PMC3984119] Related Antibodies: LS-B2081.

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ELISA Kits (22)
Sandwich (20)
Sandwich CLIA (2)
BAFF / TNFSF13B (22)
Human (7)
Mouse (7)
Rat (3)
Chicken (2)
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12 x 8-Well Microstrips (2)
96-Well Microplate (5)
96-Well Strip Plate (15)
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Cell Culture Supernatants (4)
Cell Lysates (2)
Plasma (19)
Serum (19)
Tissue Homogenates (6)
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$750
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Microplate
Mouse
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BAFF / TNFSF13B ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BAFF / TNFSF13B ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$750
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
BAFF / TNFSF13B ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
46.9 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
BAFF / TNFSF13B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).