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BAFF / TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 13b |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20 |
| Target Sequences: | NM_006573 NP_006564.1 Q9Y275 |
Publications (3)
1
SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis. Eri Itotagawa, Yoshihiko Tomofuji, Yasuhiro Kato, Hachiro Konaka, Kohei Tsujimoto, JeongHoon Park, Daiki Nagira, Takehiro Hirayama, Tatsunori Jo, Toru Hirano, Takayoshi Morita, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Yukinori Okada, Hyota Takamatsu, Atsushi Kumanogoh. Rheumatology (Oxford, England). 2023 May;62:1988-1997. [Full Text Article]
[PubMed:36094336]
[PMC:PMC10152287]
Related Antibodies: LS-B2081.
2
Elevated serum BAFF levels in patients with sarcoidosis: association with disease activity. Ueda-Hayakawa I, Tanimura H, Osawa M, Iwasaka H, Ohe S, Yamazaki F, Mizuno K, Okamoto H. Rheumatology (Oxford, England). 2013 Sep;52:1658-66. [Full Text Article]
[PubMed:23685362]
Related Antibodies: LS-B2375.
3
B Lymphocyte Stimulator (BLyS) is expressed in human adipocytes in vivo and is related to obesity but not to insulin resistance. M[Character fc]ller N, Schulte DM, Hillebrand S, T[Character fc]rk K, Hampe J, Schafmayer C, Brosch M, von Sch[Character f6]nfels W, Ahrens M, Zeuner R, Schr[Character f6]der JO, Bl[Character fc]her M, Gutschow C, Freitag-Wolf S, Stelmach-Mardas M, Saggau C, Schreiber S, Laudes M. PloS one. 2014 9:e94282. [Full Text Article]
[PubMed:24728308]
[PMC:PMC3984119]
Related Antibodies: LS-B2081.
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Publications
No
(93)
Yes
(2)
BAFF / TNFSF13B Rat anti-Human Monoclonal (aa83-285) (Buffy-1) Antibody
Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$515
BAFF / TNFSF13B Rabbit anti-Human Polyclonal (aa254-269) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
BAFF / TNFSF13B Mouse anti-Human Monoclonal (T7-241) Antibody
Human
ELISA, Flo, IHC, IHC-P
Unconjugated
50 µg/$460
BAFF / TNFSF13B Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
500 µg/$460
BAFF / TNFSF13B Rabbit anti-Human Polyclonal (aa265-285) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
BAFF / TNFSF13B Mouse anti-Human Monoclonal (Biotin) (ANC2H3) Antibody
Human
ELISA, Flo, Func
Biotin Conjugated
100 µg/$536
BAFF / TNFSF13B Mouse anti-Human Monoclonal (aa134-285) (H4-C7) Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
BAFF / TNFSF13B Mouse anti-Human Monoclonal (Azide-free) (ANC2H3) Antibody
Human
ELISA, Func
Unconjugated, Azide-free
100 µg/$446
BAFF / TNFSF13B Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
BAFF / TNFSF13B Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
BAFF / TNFSF13B Rat anti-Human Monoclonal Antibody
Mouse, Human
Flo, IHC, WB
Unconjugated
100 µg/$543
BAFF / TNFSF13B Rat anti-Human Monoclonal (4.62) Antibody
Human
ELISA, Func, IP
Unconjugated
100 µg/$463
BAFF / TNFSF13B Rat anti-Human Monoclonal (Biotin) (4.62) Antibody
Human
ELISA, Func, IP
Biotin Conjugated
100 µg/$484
BAFF / TNFSF13B Mouse anti-Human Monoclonal (6C3A2) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
BAFF / TNFSF13B Rabbit anti-Human Polyclonal (aa76-285) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
BAFF / TNFSF13B Mouse anti-Human Monoclonal (2C11) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
BAFF / TNFSF13B Rabbit anti-Human Polyclonal Antibody
Human
Flo, IP, WB
Unconjugated
100 µl/$412
BAFF / TNFSF13B Rat anti-Rat Monoclonal (Biotin) Antibody
Mouse, Rat
ELISA, Flo
Biotin Conjugated
100 µg/$924
BAFF / TNFSF13B Rabbit anti-Human Polyclonal (aa134-285) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
BAFF / TNFSF13B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
BAFF / TNFSF13B Rabbit anti-Human Monoclonal (Preservative Free) (305) Antibody
Human
WB
Unconjugated, Preservative Free
100 µl/$412
BAFF / TNFSF13B Rabbit anti-Mouse Polyclonal (aa68-302) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
BAFF / TNFSF13B Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, Flo, WB
Unconjugated
100 µg/$574
BAFF / TNFSF13B Rabbit anti-Human Polyclonal (aa16-44) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
BAFF / TNFSF13B Mouse anti-Human Monoclonal (Azide-free, BSA-free) (C257/1638) Antibody
Human
Flo, IF
Unconjugated, Azide-free, BSA-free
100 µg/$574
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