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BAD
BCL2-associated agonist of cell death
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax. Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival, whereas JNK-induced phosphorylation promotes the apoptotic role of Bad.
| Gene Name: | BCL2-associated agonist of cell death |
| Family/Subfamily: | Apoptosis , Not assigned-Other |
| Synonyms: | BAD, BBC2, Bcl-2-like protein 8, BCL2-binding component 6, BCL2L8, BBC6, BCL-X/BCL-2 binding protein, Bcl-2-binding component 6, Bcl2 antagonist of cell death, BCL2-binding protein, Bcl2-L-8 |
| Target Sequences: | NM_004322 NP_004313.1 Q92934 |
Publications (2)
1
Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:4892-7. (WB, IP)
[PubMed:18347331]
[PMC:PMC2290755]
2
Acheron/Larp6 Is a Survival Protein That Protects Skeletal Muscle From Programmed Cell Death During Development. Ankur Sheel, Rong Shao, Christine Brown, Joanne Johnson, Alexandra Hamilton, Danhui Sun, Julia Oppenheimer, Wendy Smith, Pablo E Visconti, Michele Markstein, Carol Bigelow, Lawrence M Schwartz. Frontiers in cell and developmental biology. 2020 August;8:622. [Full Text Article]
[PubMed:32850788]
[PMC:PMC7405549]
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Publications
No
(325)
BAD Rabbit anti-Mouse Polyclonal Antibody
Drosophila, Pig, Rat, Hamster, Rabbit, Mouse, Dog, Sheep, Bovine, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$505
BAD Rabbit anti-Human Polyclonal (pSer118) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
BAD Rabbit anti-Mouse Monoclonal (pSer136) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$665
BAD Rabbit anti-Human Polyclonal (pSer136) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Neuroscience
BAD Rabbit anti-Human Polyclonal Antibody
Rat
IHC-P, WB
Unconjugated
50 µg/$460
BAD Rabbit anti-Mouse Polyclonal (pSer112) Antibody
Mouse, Rat, Human, Monkey
ELISA, IP, WB
Unconjugated
100 µl/$688
BAD Rabbit anti-Human Monoclonal (Pro102) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$469; 100 µl/$702
Neuroscience
BAD Rabbit anti-Human Polyclonal (aa119-168) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
BAD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
BAD Rabbit anti-Human Polyclonal (pSer134) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
BAD Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IP, WB
Unconjugated
50 µl/$393
BAD Rabbit anti-Human Polyclonal (pSer155) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
BAD Rabbit anti-Human Polyclonal (pSer99) Antibody
Human
DB, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
BAD Rabbit anti-Human Polyclonal (30-110 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BAD Rabbit anti-Human Polyclonal (70-150 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BAD Rabbit anti-Human Polyclonal (pSer134) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
BAD Rabbit anti-Human Polyclonal (70-150 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BAD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
BAD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BAD Rabbit anti-Human Polyclonal (aa92-127) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
BAD Rabbit anti-Human Polyclonal (Pro130) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
BAD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
BAD Rabbit anti-Human Polyclonal Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
BAD Rabbit anti-Mouse Polyclonal (aa2-23) Antibody
Mouse, Rat
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
BAD Rabbit anti-Human Polyclonal (pSer99) Antibody
Human
DB, ELISA, IHC, WB
Unconjugated
200 µl/$734
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