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BACH1 is a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
Gene Name: | BTB and CNC homology 1, basic leucine zipper transcription factor 1 |
Synonyms: | BACH1, BTB and CNC homolog 1, HA2303, BACH-1 |
Target Sequences: | NM_001186 NP_001177.1 O14867 |
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