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B2M / Beta 2 Microglobulin

beta-2-microglobulin

B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Gene Name: beta-2-microglobulin
Synonyms: B2M, Beta 2 Microglobulin, Beta-2-microglobulin, Beta-2-microglobin
Target Sequences: NM_004048 NP_004039.1 P61769

Publications (9)

1
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:13794-9. [PubMed:20639463] [PMC:PMC2922274] Related Antibodies: LS-B2200.
2
Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. Rizvi SM, Del Cid N, Lybarger L, Raghavan M. Journal of immunology (Baltimore, Md. : 1950). 2011 186:2309-20. [PubMed:21263072] [PMC:PMC3057457] Related Antibodies: LS-B2200.
3
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS. Journal of immunology (Baltimore, Md. : 1950). 2012 188:4951-8. [PubMed:22490869] [PMC:PMC3345046] Related Antibodies: LS-B2200.
4
Young bone marrow transplantation preserves learning and memory in old mice. Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. Communications biology. 2019 February;2:73. [Full Text Article] [PubMed:30820468] [PMC:PMC6382867]
5
Platelet-derived ß2M regulates monocyte inflammatory responses. Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante AA, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. JCI insight. 2019 March;4:pii: 122943. [Full Text Article] [PubMed:30702442] [PMC:PMC6483513]
6
Platelet-derived ß2m regulates age related monocyte/macrophage functions. Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN. Aging. 2019 December;11:11955-11974. [Full Text Article] [PubMed:31852838] [PMC:PMC6949047]
7
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Jillian F Wise, Sigve Nakken, Chloé B Steen, Daniel Vodák, Gunhild Trøen, Bjarne Johannessen, Ole Christian Lingjærde, Vera Hilden, Yngvild Nuvin Blaker, Baoyan Bai, Lars Birger Aasheim, Annika Pasanen, Susanne Lorenz, Anita Sveen, Ragnhild A Lothe, Ola Myklebost, Sirpa Leppä, Leonardo A Meza-Zepeda, Klaus Beiske, Michael S Lawrence, Eivind Hovig, June Helen Myklebust, Erlend B Smeland, Harald Holte. Blood Advances. 2020 May;4:1859-1866. [Full Text Article] [PubMed:32374878] [PMC:PMC7218413] Related Antibodies: LS-B2200.
8
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker10<sup> The Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, UK. sm460@le.ac.uk. Marta Poblocka, Akang Leonard Bassey , Victoria M Smith, Marta Falcicchio , Ana Sousa Manso, Mohammad Althubiti , XiaoBo Sheng, Andrew Kyle, Ruth Barber, Mark Frigerio, Salvador Macip. Scientific reports. 2021 Oct;11:20358. [Full Text Article] [PubMed:34645909] [PMC:PMC8514501] Related Antibodies: LS-B2200.
9
ß2<sub>-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Daniel Hofbauer, Dimitrios Mougiakakos, Luca Broggini, Mario Zaiss, Maike Büttner-Herold, Christian Bach, Bernd Spriewald, Frank Neumann, Savita Bisht, Jens Nolting, Robert Zeiser, Shaima'a Hamarsheh, Martin Eberhardt, Julio Vera, Cristina Visentin, Chiara Maria Giulia De Luca, Fabio Moda, Stefan Haskamp, Cindy Flamann, Martin Böttcher, Katrin Bitterer, Simon Völkl, Andreas Mackensen, Stefano Ricagno, Heiko Bruns. Immunity. 2021 August;54:1772-1787e9. [Full Text Article] [PubMed:34289378] Related Antibodies: LS-B2200.
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Products
Proteins (31)
Native (1)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (26)
B2M / Beta 2 Microglobulin (31)
SDS-PAGE (2)
No (31)
10His, N-terminus + Myc, C-terminus (1)
6His, C-terminus (1)
6His, N-terminus (6)
DDK,C-terminus (1)
Fc, C-terminus (1)
GST (1)
His (6)
His, N-Terminal (1)
His, N-terminus (2)
His,C-terminus (5)
His-GST (1)
Myc-DDK (Flag) (3)
Crab-eating macaque (2)
Dog (1)
Human (18)
Mouse (4)
Rat (3)
Sheep (1)
293T Cells (1)
E. coli (11)
HEK 293 Cells (9)
Human (2)
Human Cells (3)
Mammalian Cells (3)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (7)
Low endotoxin level (11)
B2M / Beta 2 Microglobulin Protein - Recombinant Beta-2-Microglobulin By SDS-PAGE
Select
E. coli
His, N-Terminal
12.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
B2M / Beta 2 Microglobulin Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
6His, N-terminus
14 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432; 250 µg/$726; 500 µg/$1,270
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
100 µg/$532; 1 mg/$2,785
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.77kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
B2M / Beta 2 Microglobulin Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse B2M comprises 110 amino acids and has a calculated molecular mass of 13 kDa. The apparent molecular mass of rmB2M is approximately 15 kDa in SDS-PAGE under reducing conditions.
50 µg/$441; 1 mg/$2,324
B2M / Beta 2 Microglobulin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Human
None
1 mg/$777; 10 mg/$3,335
B2M / Beta 2 Microglobulin Protein
Select
E. coli
His
10 µg/$279; 50 µg/$373; 20 µg/$329; 100 µg/$479; 250 µg/$769; 500 µg/$1,243
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14kD
10 µg/$233; 50 µg/$269; 500 µg/$508; 1 mg/$664
B2M / Beta 2 Microglobulin Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human B2M consists of 110 amino acids and migrates as an approximately 13.5 kDa band in SDS-PAGE under reducing conditions as predicted.
100 µg/$403; 1 mg/$1,697
B2M / Beta 2 Microglobulin Protein - Eukaryotic Beta-2-Microglobulin By SDS-PAGE
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Human
None
13.2kDa
50 µg/$622; 10 µg/$310; 200 µg/$1,185; 100 µg/$992; 1 mg/$2,410; 500 µg/$1,915; 5 mg/$4,341; 2 mg/$2,603
B2M / Beta 2 Microglobulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
13.71 kDa
20 µg/$150
B2M / Beta 2 Microglobulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
13.71 kDa
100 µg/$494
B2M / Beta 2 Microglobulin Protein - Purified recombinant protein B2M was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
11.7 kDa
20 µg/$1,107
B2M / Beta 2 Microglobulin Protein
Select
Sf9 Cells
DDK,C-terminus
12 kDa
20 µg/$677
B2M / Beta 2 Microglobulin Protein - Recombinant Mouse B2M/ß2-MG Protein (His Tag)-Elabsicence
Select
E. coli
His, N-terminus
11.64kDa
20 µg/$270; 100 µg/$390
Select
E. coli
His, N-terminus
11.6kDa
20 µg/$270; 100 µg/$390
B2M / Beta 2 Microglobulin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
18.6 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.0 kDa
10 µg/$233; 50 µg/$269
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.5 kDa
10 µg/$277; 50 µg/$389
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.8 kDa
10 µg/$277; 50 µg/$389
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.77 kDa
10 µg/$288; 50 µg/$436
Select
HEK 293 Cells
His
13.2 kDa
10 µg/$335; 50 µg/$622; 100 µg/$932
B2M / Beta 2 Microglobulin Protein - 12.5% SDS-PAGE of human B2M stained with Coomassie Blue
Select
Wheat Germ Extract
GST
38.83 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
6His, N-terminus
13.5 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
HEK 293 Cells
6His, N-terminus
13.5 kDa
100 µg/$298
Viewing 1-25 of 31 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).