AXL

AXL receptor tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

AXL (13)

Publications

No (13)

Tag

6His, C-terminus (2)

Fc, C-terminus (1)

GST (1)

GST, N-terminus (2)

His (1)

His,C-terminus (1)

His-Fc (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (4)

Rat (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Human (3)

Human Cells (2)

Wheat Germ Extract (3)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (6)

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Human AXL Protein (Recombinant GST) (Full Length) - LS-G27591

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

124.8 kDa

Price:

2 µg/$439

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Human AXL Protein (Recombinant His) (Met1-Pro449) - LS-G98515

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.5 kDa

Price:

100 µg/$483; 1 mg/$2,901

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Human AXL Protein (Recombinant GST, N-terminus) (aa30-140) - LS-G57868

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AXL Protein (Recombinant GST, N-terminus) (aa787-885) - LS-G57870

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AXL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79403

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.2 kDa

Price:

20 µg/$150

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Human AXL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67242

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.2 kDa

Price:

20 µg/$1,107

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AXL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110569

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.2 kDa

Price:

100 µg/$494

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Human AXL Protein (Recombinant 6His, C-terminus) - LS-G146068

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.6 kDa

Price:

10 µg/$239; 50 µg/$294

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Mouse AXL Protein (Recombinant 6His, C-terminus) - LS-G146254

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.2 kDa

Price:

10 µg/$266; 50 µg/$377

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Mouse AXL Protein (Recombinant Fc, C-terminus) - LS-G146277

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73.3 kDa

Price:

10 µg/$317; 50 µg/$529

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Mouse AXL Protein (Recombinant His,C-terminus) (Met1-Pro443) - LS-G138176

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.8 kDa

Price:

100 µg/$721

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Rat AXL Protein (Recombinant His-S) (aa21-202) - LS-G26097

Source:

E. coli

Tag:

His-S

Molecular Weight:

23.5 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Mouse AXL Protein (Recombinant His-Fc) (Met1-Pro443) - LS-G98056

Source:

Human Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

74.5 kDa

Price:

100 µg/$721

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