AXL

AXL receptor tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

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Products

ELISA Kits (12)

Type

Custom (2)

Sandwich (10)

Target

AXL (12)

Reactivity

Human (7)

Mouse (4)

Rat (1)

Format

96-Well Microplate (4)

96-Well Strip Plate (8)

Publications

No (12)

Sample Type

Cell Culture Supernatants (6)

Cell Lysates (1)

Plasma (9)

Serum (9)

Tissue Homogenates (4)

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Human AXL (Sandwich ELISA) ELISA Kit - LS-F2608

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

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Rat AXL (Sandwich ELISA) ELISA Kit - LS-F9791

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

2.34 - 150 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$848

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Human AXL (Sandwich ELISA) ELISA Kit - LS-F33

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2.743 - 666.7 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Mouse AXL (Sandwich ELISA) ELISA Kit - LS-F219

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

1.024 - 100 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Mouse AXL (Sandwich ELISA) ELISA Kit - LS-F2609

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Human AXL (Sandwich ELISA) ELISA Kit - LS-F54673

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$822

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Human AXL (Sandwich ELISA) ELISA Kit - LS-F55910

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human AXL (Sandwich ELISA) ELISA Kit - LS-F39101

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$792

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Human AXL (Sandwich ELISA) ELISA Kit - LS-F24357

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Mouse AXL (Sandwich ELISA) ELISA Kit - LS-F24713

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Mouse AXL (Custom ELISA) ELISA Kit - LS-F19762

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

Select

Human AXL (Custom ELISA) ELISA Kit - LS-F19763

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

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