AXIN2 / Axin 2

axin 2

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

AXIN2 / Axin 2 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human AXIN2 / Axin 2 Protein (Recombinant His) (aa350-631) - LS-G14833

Source:

E. coli

Tag:

His

Molecular Weight:

32.7 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human AXIN2 / Axin 2 Protein (Recombinant GST) (Full Length) - LS-G31103

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.4 kDa

Price:

2 µg/$439

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Human AXIN2 / Axin 2 Protein (Recombinant GST, N-terminus) (aa611-710) - LS-G60681

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AXIN2 / Axin 2 Protein (Recombinant GST, N-terminus) (aa745-843) - LS-G60683

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AXIN2 / Axin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85216

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.4 kDa

Price:

20 µg/$150

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AXIN2 / Axin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100359

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.4 kDa

Price:

100 µg/$494

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