AXIN1 / Axin-1

axin 1

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

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Products

ELISA Kits (6)

Type

Custom (2)

Sandwich (4)

Target

AXIN1 / Axin-1 (6)

Reactivity

Human (3)

Mouse (1)

Rat (1)

Chicken (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

Publications

No (6)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

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Human AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F35783

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

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Mouse AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F20510

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F10906

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F74439

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$595

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Chicken AXIN1 / Axin-1 (Custom ELISA) ELISA Kit - LS-F20512

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat AXIN1 / Axin-1 (Custom ELISA) ELISA Kit - LS-F20511

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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