AXIN1 / Axin-1

axin 1

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

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Products

Antibodies (80)

Proteins (9)

ELISA Kits (6)

Type

Custom (2)

Over-Expression Lysate (4)

Primary (80)

Recombinant (5)

Sandwich (4)

Target

AXIN1 / Axin-1 (95)

Reactivity

Human (57)

Mouse (33)

Rat (24)

Bat (1)

Bovine (1)

Chicken (1)

Hamster (1)

Horse (1)

Monkey (2)

Zebrafish (1)

Application

IHC (18)

IHC-P (3)

WB (75)

Flo (1)

ELISA (22)

ICC (1)

IF (2)

IP (6)

Peptide-ELISA (2)

Host

rabbit (70)

mouse (9)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (19)

IgG1 (1)

IgG2a,k (7)

IgG2b (1)

Clonality

monoclonal mc (9)

polyclonal pc (71)

Clone

2B11 (1)

4E9F1 (1)

4F10G1 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

APC (3)

APC Conjugated (8)

Atto 390 Conjugated (2)

Atto 488 Conjugated (2)

Atto 594 Conjugated (2)

Azide-free (2)

Biotin Conjugated (10)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (10)

HRP Conjugated (8)

PE Conjugated (6)

PerCP Conjugated (2)

RPE Conjugated (2)

Unconjugated (22)

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Epitope

aa618-827 (8)

aa653-862 (8)

aa654-863 (8)

aa330-359 (7)

aa710-738 (7)

aa8-62 (4)

Internal (1)

N-Terminus (1)

aa850-862 (1)

Publications

No (95)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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IHC-plus™ AXIN1 / Axin-1 Antibody LS-B6982

(4.0) Rating

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ AXIN1 / Axin-1 Antibody (aa850-862) LS-B2741

(4.0) Rating

Antibody:

AXIN1 / Axin-1 Goat anti-Human Polyclonal (aa850-862) Antibody

Reactivity:

Zebrafish, Horse, Bat, Rat, Hamster, Mouse, Bovine, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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Human AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F35783

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

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AXIN1 / Axin-1 Antibody (clone 4E9F1) LS-C682465

Antibody:

AXIN1 / Axin-1 Mouse anti-Human Monoclonal (4E9F1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, WB

Format:

Unconjugated

Price:

100 µl/$459

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Mouse AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F20510

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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AXIN1 / Axin-1 Antibody (aa710-738) LS-C156697

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse AXIN1 / Axin-1 Protein (Recombinant 6His, N-terminus) (aa654-863) - LS-G14839

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.2 kDa

Price:

10 µg/$279; 50 µg/$425; 100 µg/$680; 200 µg/$850; 1 mg/$1,944; 500 µg/$1,490; 5 mg/$2,969; 2 mg/$2,131

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AXIN1 / Axin-1 Antibody (aa330-359) LS-C319730

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa330-359) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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Human AXIN1 / Axin-1 (Sandwich ELISA) ELISA Kit - LS-F10906

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

AXIN1 / Axin-1 Antibody (clone 2B11) LS-C198545

Antibody:

AXIN1 / Axin-1 Mouse anti-Human Monoclonal (2B11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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AXIN1 / Axin-1 Antibody (aa710-738) LS-C329246

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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AXIN1 / Axin-1 Antibody (aa710-738, Biotin) LS-C252159

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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AXIN1 / Axin-1 Antibody (aa710-738, FITC) LS-C252160

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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AXIN1 / Axin-1 Antibody (aa710-738, Azide-free, HRP) LS-C252161

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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AXIN1 / Axin-1 Antibody (aa710-738, APC) LS-C252158

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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AXIN1 / Axin-1 Antibody (aa710-738, PE) LS-C252162

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (aa710-738) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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AXIN1 / Axin-1 Antibody LS-C775205

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$442

Select

AXIN1 / Axin-1 Antibody (clone 4F10G1) LS-C682472

Antibody:

AXIN1 / Axin-1 Mouse anti-Human Monoclonal (4F10G1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

AXIN1 / Axin-1 Antibody (Biotin) LS-C775204

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

100 µg/$475

Select

AXIN1 / Axin-1 Antibody (FITC) LS-C776758

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

FITC Conjugated

Price:

100 µg/$472

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AXIN1 / Axin-1 Antibody (Atto 488) LS-C775206

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Atto 488) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Atto 488 Conjugated

Price:

100 µg/$479

Select

AXIN1 / Axin-1 Antibody (Atto 594) LS-C775208

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Atto 594) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Atto 594 Conjugated

Price:

100 µg/$479

Select

AXIN1 / Axin-1 Antibody (Atto 390) LS-C775210

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (Atto 390) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Atto 390 Conjugated

Price:

100 µg/$479

Select

AXIN1 / Axin-1 Antibody (PerCP) LS-C776757

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (PerCP) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

PerCP Conjugated

Price:

100 µg/$478

Select

AXIN1 / Axin-1 Antibody (RPE) LS-C776759

Antibody:

AXIN1 / Axin-1 Rabbit anti-Human Polyclonal (RPE) Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

RPE Conjugated

Price:

100 µg/$477

• Biotin
• FITC
• Atto 488
• Atto 594
• Atto 390
• PerCP
• RPE

• Biotin
• FITC
• Atto 488
• More...
  • Atto 594
  • Atto 390
  • PerCP
  • RPE

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