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AWAT2 / DGAT2L4
acyl-CoA wax alcohol acyltransferase 2
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.
| Gene Name: | acyl-CoA wax alcohol acyltransferase 2 |
| Synonyms: | AWAT2, ARAT, DGAT2L4, HWS, MFAT, Wax synthase, DC4, HDC4, WS |
| Target Sequences: | AA969335 Q6E213 Q6E213 |
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