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Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Gene Name: | aurora kinase C |
Family/Subfamily: | Protein Kinase , Aurora/IPL1-like |
Synonyms: | AURKC, AIE2, Aie1, AIRK3, ARK-3, Aurora kinase C, Aurora-related kinase 3, AurC, Aurora 3, Aurora C, Aurora/IPL1-related kinase 3, ARK3, Aurora-C, AIK3, HsAIRK3, SPGF5, Aurora/IPL1/Eg2 protein 2, STK13 |
Target Sequences: | NM_003160 NP_003151.2 Q9UQB9 |
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