AURKA / Aurora-A

aurora kinase A

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

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Products

Proteins (21)

Type

Over-Expression Lysate (12)

Recombinant (9)

Target

AURKA / Aurora-A (21)

Publications

No (21)

Tag

GST (1)

GST, N-terminus (3)

His (1)

Myc-DDK (Flag) (16)

Species

Human (15)

Source

293T Cells (6)

E. coli (1)

HEK 293 Cells (10)

Wheat Germ Extract (4)

Purification

Purified (1)

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Human AURKA / Aurora-A Protein (Recombinant His) - LS-G573

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human AURKA / Aurora-A Protein (Recombinant GST) (Full Length) - LS-G30578

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.07 kDa

Price:

2 µg/$439

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Human AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88179

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88181

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88182

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88183

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88184

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88185

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$150

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Human AURKA / Aurora-A Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G60239

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AURKA / Aurora-A Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60240

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AURKA / Aurora-A Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G60242

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102562

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

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Human AURKA / Aurora-A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70863

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$1,107

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Human AURKA / Aurora-A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70864

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$1,107

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Human AURKA / Aurora-A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70865

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$1,107

Select

Human AURKA / Aurora-A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70866

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

20 µg/$1,107

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AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103690

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

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AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103691

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

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AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103692

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

Select

AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103693

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

Select

AURKA / Aurora-A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117225

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.6 kDa

Price:

100 µg/$494

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