ATXN1 / SCA1

ataxin 1

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

☰ Filters

Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

ATXN1 / SCA1 (9)

Publications

No (9)

Tag

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (6)

Species

Human (6)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Select

Mouse ATXN1 / SCA1 Protein (Recombinant His-T7) (aa331-587) - LS-G12266

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.9 kDa

Price:

50 µg/$470; 10 µg/$285; 200 µg/$937; 100 µg/$750; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

Select

Human ATXN1 / SCA1 Protein (Recombinant His-T7) (aa569-807) - LS-G12267

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

Select

Human ATXN1 / SCA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65014

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

20 µg/$1,107

Select

Human ATXN1 / SCA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65015

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

20 µg/$1,107

Select

Human ATXN1 / SCA1 Protein (Recombinant GST, N-terminus) (aa576-675) - LS-G60031

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human ATXN1 / SCA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74636

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

20 µg/$215

Select

Human ATXN1 / SCA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74635

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

20 µg/$215

Select

ATXN1 / SCA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124752

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

100 µg/$710

Select

ATXN1 / SCA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123259

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

100 µg/$710

Viewing 1-9 of 9 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.