ATXN1 / SCA1

ataxin 1

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

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Products

ELISA Kits (16)

Type

Competitive EIA (1)

Sandwich (12)

Sandwich CLIA (3)

Target

ATXN1 / SCA1 (16)

Reactivity

Human (4)

Mouse (3)

Rat (3)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (3)

96-Well Strip Plate (10)

Publications

No (16)

Sample Type

Plasma (10)

Serum (10)

Tissue Homogenates (3)

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Human ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F21955

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human ATXN1 / SCA1 (CLIA) ELISA Kit - LS-F29448

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Guinea pig ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F41506

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Chicken ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F41507

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F41508

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Porcine ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F41509

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F41510

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Sheep ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F41511

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$691

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Mouse ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F34475

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F34476

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F34477

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse ATXN1 / SCA1 (CLIA) ELISA Kit - LS-F30514

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

7.813 - 500 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rat ATXN1 / SCA1 (CLIA) ELISA Kit - LS-F31103

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rat ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F22284

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F23036

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human ATXN1 / SCA1 (Competitive EIA) ELISA Kit - LS-F28762

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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