ATXN1 / SCA1

ataxin 1

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

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Antibodies (78)

ELISA Kits (16)

Proteins (9)

Type

Competitive EIA (1)

Over-Expression Lysate (4)

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ATXN1 / SCA1 (103)

Reactivity

Human (68)

Mouse (64)

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Chicken (1)

Drosophila (1)

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rabbit (45)

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monoclonal mc (33)

polyclonal pc (45)

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2B8A2 (1)

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Epitope

aa164-197 (9)

aa746-761 (9)

aa331-587 (8)

aa569-807 (8)

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720-800 aa (2)

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No (103)

Sample Type

Plasma (10)

Serum (10)

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GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (6)

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Mouse (1)

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IHC-plus™ ATXN1 / SCA1 Antibody (aa742-791) LS-B5679

(4.0) Rating

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (aa742-791) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$460

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Human ATXN1 / SCA1 (Sandwich ELISA) ELISA Kit - LS-F21955

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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ATXN1 / SCA1 Antibody (aa331-587) LS-C314530

Antibody:

ATXN1 / SCA1 Rabbit anti-Mouse Polyclonal (aa331-587) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161

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ATXN1 / SCA1 Antibody (720-800 aa) LS-C382169

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (720-800 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IHC-plus™ ATXN1 / SCA1 Antibody (C-Terminus) LS-B14568

(4.0) Rating

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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ATXN1 / SCA1 Antibody LS-C813986

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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ATXN1 / SCA1 Antibody (clone 4C7B11) LS-C828394

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (4C7B11) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µg/$459

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ATXN1 / SCA1 Antibody (clone 2F5) LS-C169295

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (2F5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$435

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ATXN1 / SCA1 Antibody (C-Terminus) LS-C358916

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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ATXN1 / SCA1 Antibody LS-C92171

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Drosophila, Rat, Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$688

Select

ATXN1 / SCA1 Antibody LS-C417564

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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ATXN1 / SCA1 Antibody LS-C334567

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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ATXN1 / SCA1 Antibody (aa164-197, clone S76-8, RPE) LS-C229240

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (aa164-197) (RPE) (S76-8) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, WB

Format:

RPE Conjugated

Price:

100 µg/$477

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ATXN1 / SCA1 Antibody (clone 2F5) LS-C758902

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (2F5) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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ATXN1 / SCA1 Antibody (aa746-761, clone S65-37, PerCP) LS-C229404

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (aa746-761) (PerCP) (S65-37) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

PerCP Conjugated

Price:

100 µg/$478

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ATXN1 / SCA1 Antibody (clone 13B55) LS-C183470

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (13B55) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$688

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ATXN1 / SCA1 Antibody LS-C808663

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ATXN1 / SCA1 Antibody (720-800 aa) LS-C381131

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (720-800 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ATXN1 / SCA1 Antibody (clone 2B8A2) LS-C828352

Antibody:

ATXN1 / SCA1 Mouse anti-Human Monoclonal (2B8A2) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µg/$459

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ATXN1 / SCA1 Antibody LS-C404727

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

ATXN1 / SCA1 Antibody (phospho-Ser775) LS-C801117

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (pSer775) Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

ATXN1 / SCA1 Antibody LS-C822112

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

ATXN1 / SCA1 Antibody (phospho-Ser775) LS-C416722

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (pSer775) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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ATXN1 / SCA1 Antibody (Ser776) LS-C97295

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (Ser776) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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ATXN1 / SCA1 Antibody (aa778-808) LS-C407636

Antibody:

ATXN1 / SCA1 Rabbit anti-Human Polyclonal (aa778-808) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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