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ATR
ataxia telangiectasia and Rad3 related
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
| Gene Name: | ataxia telangiectasia and Rad3 related |
| Family/Subfamily: | Protein Kinase , PI3/PI4 |
| Synonyms: | ATR, FRAP-related protein-1, FCTCS, SCKL1, MEC1, Protein kinase ATR, Rad3 related protein, SCKL, FRAP-related protein 1, FRP1, XATR, Serine/threonine-protein kinase ATR, Ataxia telangiectasia and Rad3-related protein, mitosis entry checkpoint 1 |
| Target Sequences: | NM_001184 NP_001175.2 Q13535 |
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