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ATP6V1F is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein.
Gene Name: | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F |
Family/Subfamily: | Transporter , ATPase - V type |
Synonyms: | ATP6V1F, ATPase, vacuolar, 14 kD, V-ATPase subunit F, Vacuolar proton pump F subunit, Vma7, V-ATPase F subunit, ATP6S14, Vacuolar proton pump subunit F, V-ATPase 14 kDa subunit, V-type proton ATPase subunit F, VATF |
Target Sequences: | NM_004231 NP_004222.2 Q16864 |
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