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ATP6V1C2
ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C2
ATP6V1C2 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.
| Gene Name: | ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C2 |
| Synonyms: | ATP6V1C2, ATP6C2, V-ATPase subunit C 2, Vma5, V-ATPase C2 subunit |
| Target Sequences: | AA532845 NP_001034451.1 |
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