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Newark, CA 94560
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ATP6E / ATP6V1E1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP6E / ATP6V1E1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
| Gene Name: | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 |
| Family/Subfamily: | Transporter , ATPase - V type |
| Synonyms: | ATP6V1E1, ATP6E, ATP6E2, ATP6V1E, V-ATPase subunit E 1, V-ATPase, subunit E, V-ATPase 31 kDa subunit, p31, V-ATPase subunit E, VMA4 |
| Target Sequences: | NM_001696 NP_001687.1 P36543 |
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