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ATP1A2

Atpase, Na+/K+ Transporting, Alpha 2 Polypeptide

ATP1A2 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.

Gene Name: Atpase, Na+/K+ Transporting, Alpha 2 Polypeptide
Family/Subfamily: Transporter , ATPase - P type, type IIC
Synonyms: ATP1A2, Atpa3, FHM2, KIAA0778, MHP2, Migraine, hemiplegic 2, Sodium-potassium ATPase, Sodium pump subunit alpha-2, Sodium pump 2, Sodium/potassium ATPase 2
Target Sequences: NM_000702 NP_000693.1 P50993

Publications (1)

1
Insulin and a-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury. Irina O Zakharova, Liubov V Bayunova, Inna I Zorina, Tatiana V Sokolova, Alexander O Shpakov, Natalia F Avrova. International journal of molecular sciences. 2021 Oct;22:11768. [Full Text Article] [PubMed:34769198] [PMC:PMC8584186] Related Antibodies: LS-C368564.

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ATP1A2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
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112.1 kDa
20 µg/$150
ATP1A2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
112.1 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).