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ATP1A2 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Gene Name: | Atpase, Na+/K+ Transporting, Alpha 2 Polypeptide |
Family/Subfamily: | Transporter , ATPase - P type, type IIC |
Synonyms: | ATP1A2, Atpa3, FHM2, KIAA0778, MHP2, Migraine, hemiplegic 2, Sodium-potassium ATPase, Sodium pump subunit alpha-2, Sodium pump 2, Sodium/potassium ATPase 2 |
Target Sequences: | NM_000702 NP_000693.1 P50993 |
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