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ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Family/Subfamily: Transporter , ATPase - P type, type IIC
Synonyms: ATP1A1, Na+, K+ ATPase alpha subunit, Na,K-ATPase alpha-1 subunit, Na+/K+ ATPase 1, Sodium pump 1, Sodium pump subunit alpha-1
Target Sequences: NM_000701 NP_000692.2 P05023

Publications (39)

1
Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. McDonough AA, Zhang Y, Shin V, Frank JS. The American journal of physiology. 1996 270:C1221-7. [PubMed:8928749]
2
Reversible effects of acute hypertension on proximal tubule sodium transporters. Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1998 274:C1090-100. [PubMed:9575807]
3
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1999 276:F711-9. [PubMed:10330053]
4
Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. American journal of physiology. Renal physiology. 2000 279:F358-69. [PubMed:10919857]
5
18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding. Farley RA, Elquza E, Mller-Ehmsen J, Kane DJ, Nagy AK, Kasho VN, Faller LD. Biochemistry. 2001 40:6361-70. [PubMed:11371198]
6
All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Wang J, Velotta JB, McDonough AA, Farley RA. American journal of physiology. Cell physiology. 2001 281:C1336-43. (WB; Human) [PubMed:11546672]
7
Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough AA. American journal of physiology. Renal physiology. 2003 284:F1056-65. [PubMed:12554635]
8
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A. The Journal of biological chemistry. 2004 279:15167-76. [PubMed:14732719]
9
Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake. Knox CD, Belous AE, Pierce JM, Wakata A, Nicoud IB, Anderson CD, Pinson CW, Chari RS. American journal of physiology. Gastrointestinal and liver physiology. 2004 287:G533-40. (WB; Rat) [PubMed:15107298]
10
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W. Molecular biology of the cell. 2005 16:24-31. [PubMed:15496455] [PMC:PMC539148]
11
Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism. Shah M, Patel K, Sehgal PB. American journal of physiology. Cell physiology. 2005 288:C850-62. [PubMed:15561761]
12
A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function. Cross WR, Eardley I, Leese HJ, Southgate J. American journal of physiology. Renal physiology. 2005 289:F459-68. [PubMed:15784840]
13
Effects of ACE inhibition on proximal tubule sodium transport. Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough AA. American journal of physiology. Renal physiology. 2006 290:F854-63. [PubMed:16263808]
14
The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase. Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R. Journal of leukocyte biology. 2006 80:630-9. [PubMed:16844764]
15
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB. The Journal of biological chemistry. 2006 281:38071-9. [PubMed:17038320] [PMC:PMC1847411]
16
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein. Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL. Journal of lipid research. 2007 48:1022-34. [PubMed:17293612]
17
Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice. Qu S, Perdomo G, Su D, D'Souza FM, Shachter NS, Dong HH. Journal of lipid research. 2007 48:1476-87. [PubMed:17438339] [PMC:PMC2665252]
18
Lipid rafts are required for Kit survival and proliferation signals. Jahn T, Leifheit E, Gooch S, Sindhu S, Weinberg K. Blood. 2007 110:1739-47. [PubMed:17554062] [PMC:PMC1976347]
19
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M, Bunnett NW. The Journal of cell biology. 2007 179:981-97. [PubMed:18039931] [PMC:PMC2099187]
20
Evolutionarily conserved gene family important for fat storage. Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N, Torregroza I, Evans T, Silver DL. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:94-9. [PubMed:18160536] [PMC:PMC2224239]
21
Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling. Winterstein C, Trotter J, Krmer-Albers EM. Journal of cell science. 2008 121:834-42. [PubMed:18303048]
22
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo. Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Ltjohann D, Demattos RB, Wellington CL. Journal of lipid research. 2008 49:1254-67. [PubMed:18314463]
23
Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization. Dayem M, Basquin C, Navarro V, Carrier P, Marsault R, Chang P, Huc S, Darrouzet E, Lindenthal S, Pourcher T. The Journal of endocrinology. 2008 197:95-109. [PubMed:18372236]
24
Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. Peyrottes I, Navarro V, Ondo-Mendez A, Marcellin D, Bellanger L, Marsault R, Lindenthal S, Ettore F, Darcourt J, Pourcher T. European journal of endocrinology / European Federation of Endocrine Societies. 2009 160:215-25. [PubMed:19029227]
25
Development and validation of a novel protein extraction methodology for quantitation of protein expression in formalin-fixed paraffin-embedded tissues using western blotting. Nirmalan NJ, Harnden P, Selby PJ, Banks RE. The Journal of pathology. 2009 217:497-506. [PubMed:19156775]
26
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes. Feldmann A, Winterstein C, White R, Trotter J, Krmer-Albers EM. Journal of neuroscience research. 2009 87:1760-72. [PubMed:19185015]
27
A mouse model for degeneration of the spiral ligament. Kada S, Nakagawa T, Ito J. Journal of the Association for Research in Otolaryngology : JARO. 2009 10:161-72. (IHC) [PubMed:19212789] [PMC:PMC2674195]
28
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW. The Journal of biological chemistry. 2009 284:22411-25. [PubMed:19531493] [PMC:PMC2755963]
29
Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. Zhang Y, Liu R, Ni M, Gill P, Lee AS. The Journal of biological chemistry. 2010 285:15065-75. [PubMed:20208072] [PMC:PMC2865300]
30
Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis. Li H, Ganta S, Fong P. Experimental physiology. 2010 95:1132-44. [PubMed:20729267] [PMC:PMC2991370]
31
Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?. Krmer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mbius W, Berger H, Nave KA, Schild H, Trotter J. Proteomics. Clinical applications. 2007 1:1446-61. [PubMed:21136642]
32
Critical role for CD38-mediated Ca2+ signaling in thrombin-induced procoagulant activity of mouse platelets and hemostasis. Mushtaq M, Nam TS, Kim UH. The Journal of biological chemistry. 2011 286:12952-8. [PubMed:21339289] [PMC:PMC3075642]
33
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Thimiri Govinda Raj DB, Ghesquire B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W. Molecular systems biology. 2011 7:541. [PubMed:22027552] [PMC:PMC3261717]
34
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P. The EMBO journal. 2012 31:1062-79. [PubMed:22252128] [PMC:PMC3298003]
35
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Chun KH, Araki K, Jee Y, Lee DH, Oh BC, Huang H, Park KS, Lee SW, Zabolotny JM, Kim YB. Endocrinology. 2012 153:1649-62. (WB; Mouse) [PubMed:22355071] [PMC:PMC3320261]
36
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Molecular pharmacology. 2012 82:591-600. [PubMed:22740639] [PMC:PMC3463226]
37
Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity. Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S. The Journal of biological chemistry. 2012 287:35860-72. (ICC; Mouse) [PubMed:22865855] [PMC:PMC3476255]
38
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling. Le Goff A, Ji Z, Leclercq B, Bourette RP, Mougel A, Guerardel C, de Launoit Y, Vicogne J, Goormachtigh G, Fafeur V. The Journal of biological chemistry. 2012 287:35382-96. (WB; Dog) [PubMed:22915589] [PMC:PMC3471683]
39
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chvez-Gutirrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken. Neuron. 2012 75:1008-21. (WB; Drosophila) [PubMed:22998870]
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No (92)
ATP1A1 Antibody - Anti-ATP1A1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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IHC-plus™ ATP1A1 Antibody (aa5-54) LS-B6994
(4.0) Rating
ATP1A1 Rabbit anti-Human Polyclonal (aa5-54) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ATP1A1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ ATP1A1 Antibody (Internal) LS-B13592
(4.0) Rating
ATP1A1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ATP1A1 Antibody - Staining of endometrial glands within the uterus using ATPase alpha 1 (Na/K) [clone 464.6] antibody. Note the absence of staining in the surrounding myometrial smooth muscle.
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ATP1A1 Antibody (clone 464.6 (6H)) LS-C2766
ATP1A1 Mouse anti-Rabbit Monoclonal (464.6 (6H)) Antibody
Xenopus, Pig, Rat, Rabbit, Mouse, Dog, Sheep, Human, Primate
Flo, ICC, IHC, WB
Unconjugated
0.05 ml/$386
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ATP1A1 Antibody LS-C20809
ATP1A1 Mouse anti-Rabbit Monoclonal Antibody
Xenopus, Rat, Pig, Mouse, Dog, Human, Monkey
IHC, IP, WB
Unconjugated
50 µg/$957
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ATP1A1 Antibody (aa338-518) LS-C20813
ATP1A1 Rabbit anti-Rat Polyclonal (aa338-518) Antibody
Bovine, Rat
ICC, IHC, IHC-Fr, IP, WB
Unconjugated
50 µg/$657
ATP1A1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IHC-plus™ ATP1A1 Antibody LS-B13294
(4.0) Rating
ATP1A1 Mouse anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
ATP1A1 Antibody - Immunohistochemical analysis of ATP1A1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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ATP1A1 Antibody (N-Terminus) LS-C354554
ATP1A1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
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ATP1A1 Antibody LS-C663982
ATP1A1 Mouse anti-Human Monoclonal Antibody
Human
Unconjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614
ATP1A1 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using ATPase (Phospho-Ser16) Antibody. The picture on the right is blocked with the phospho peptide.
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ATP1A1 Antibody (phospho-Ser16) LS-C198653
ATP1A1 Rabbit anti-Human Polyclonal (pSer16) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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ATP1A1 Antibody (N-Terminus) LS-C35070
ATP1A1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Hamster, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$688
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ATP1A1 Antibody LS-C755082
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µg/$341
ATP1A1 Antibody - 1:100 staining mouse intestine tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ATP1A1 Antibody (phospho-Ser16) LS-C800943
ATP1A1 Rabbit anti-Human Polyclonal (pSer16) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATP1A1 Antibody - 1:50 dilution staining ATPase in human brain by IHC using paraffin-embedded tissue
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ATP1A1 Antibody LS-C801543
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATP1A1 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using ATPase (Ab-16) antibody.
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ATP1A1 Antibody (p16) LS-C821810
ATP1A1 Rabbit anti-Human Polyclonal (p16) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
ATP1A1 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using ATP1A1 Antibody at dilution of 1:100
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ATP1A1 Antibody LS-C500353
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
ATP1A1 Antibody - Western blot of Na+/K+-ATPase alpha1 antibody
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ATP1A1 Antibody (1-80 aa) LS-C384759
ATP1A1 Rabbit anti-Human Polyclonal (1-80 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ATP1A1 Antibody - IHC of Na+/K+-ATPase 1 (Y10) pAb in paraffin-embedded human breast carcinoma tissue.
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ATP1A1 Antibody (Tyr10) LS-C176312
ATP1A1 Rabbit anti-Human Polyclonal (Tyr10) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
ATP1A1 Antibody - Western blot of ATP1alpha1/Na+K+ ATPase1 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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ATP1A1 Antibody LS-C417386
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
ATP1A1 Antibody - Western blot of ATP1 alpha1/Na+K+ ATPase1 phosphorylation expression in Rat brain tissue lysates,The lane on the left is treated with the antigen-specific peptide.
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ATP1A1 Antibody (phospho-Ser23) LS-C416491
ATP1A1 Rabbit anti-Human Polyclonal (pSer23) Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
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ATP1A1 Antibody (1-80 aa) LS-C381240
ATP1A1 Rabbit anti-Human Polyclonal (1-80 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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ATP1A1 Antibody LS-C659339
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ATP1A1 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ATPase (Phospho-Ser16) antibody.
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ATP1A1 Antibody (phospho-Ser16) LS-C821808
ATP1A1 Rabbit anti-Human Polyclonal (pSer16) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ATP1A1 Antibody - Staining PC-12 cells treated with TPA cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% saponin prior to blocking in 10% serum for 45 min at 37°C. The primary antibody was diluted 1/400 and incubated with the sample for 1 hour at 37°C. A Alexa Fluor® 594 conjugated goat polyclonal to rabbit IgG (H+L), diluted 1/600 was used as secondary antibody.
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ATP1A1 Antibody (phospho-Ser23) LS-C800970
ATP1A1 Rabbit anti-Human Polyclonal (pSer23) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATP1A1 Antibody - Western blot of Phospho-Na+/K+-ATPase alpha1 (pSer16) antibody
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ATP1A1 Antibody (phospho-Ser16) LS-C381157
ATP1A1 Rabbit anti-Rat Polyclonal (pSer16) Antibody
Rat
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ATP1A1 Antibody - Western blot of Na+/K+-ATPase 1 (G19) pAb in extracts from HeLa cells.
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ATP1A1 Antibody (Gly19) LS-C177335
ATP1A1 Rabbit anti-Human Polyclonal (Gly19) Antibody
Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
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