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ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | ATPase, Na+/K+ transporting, alpha 1 polypeptide |
| Family/Subfamily: | Transporter , ATPase - P type, type IIC |
| Synonyms: | ATP1A1, Na+, K+ ATPase alpha subunit, Na,K-ATPase alpha-1 subunit, Na+/K+ ATPase 1, Sodium pump 1, Sodium pump subunit alpha-1 |
| Target Sequences: | NM_000701 NP_000692.2 P05023 |
Publications (39)
1
Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. McDonough AA, Zhang Y, Shin V, Frank JS. The American journal of physiology. 1996 270:C1221-7.
[PubMed:8928749]
2
Reversible effects of acute hypertension on proximal tubule sodium transporters. Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1998 274:C1090-100.
[PubMed:9575807]
3
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1999 276:F711-9.
[PubMed:10330053]
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ATP1A1 Rabbit anti-Human Polyclonal (aa5-54) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ATP1A1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
![ATP1A1 Antibody - Staining of endometrial glands within the uterus using ATPase alpha 1 (Na/K) [clone 464.6] antibody. Note the absence of staining in the surrounding myometrial smooth muscle.](https://lsbio-7d62.kxcdn.com/image2/atp1a1-antibody-clone-464.6-6h-ls-c2766/3439_5108127.jpg)
ATP1A1 Mouse anti-Rabbit Monoclonal (464.6 (6H)) Antibody
Xenopus, Pig, Rat, Rabbit, Mouse, Dog, Sheep, Human, Primate
Flo, ICC, IHC, WB
Unconjugated
0.05 ml/$386
ATP1A1 Mouse anti-Rabbit Monoclonal Antibody
Xenopus, Rat, Pig, Mouse, Dog, Human, Monkey
IHC, IP, WB
Unconjugated
50 µg/$957
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$958
Sandwich
96-Well Strip Plate
Rabbit
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$783
HEK 293 Cells
Myc-DDK (Flag)
112.7 kDa
20 µg/$1,107
ATP1A1 Rabbit anti-Rat Polyclonal (aa338-518) Antibody
Bovine, Rat
ICC, IHC, IHC-Fr, IP, WB
Unconjugated
50 µg/$657
ATP1A1 Mouse anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
ATP1A1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
ATP1A1 Mouse anti-Human Monoclonal Antibody
Human
Unconjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614
Cell-Based Phosphorylation
96-Well Microplate
Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATP1A1 Rabbit anti-Human Polyclonal (pSer16) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ATP1A1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Hamster, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$688
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µg/$341
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATP1A1 Rabbit anti-Human Polyclonal (pSer16) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ATP1A1 Rabbit anti-Human Polyclonal (p16) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
ATP1A1 Rabbit anti-Human Polyclonal (1-80 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ATP1A1 Rabbit anti-Human Polyclonal (Tyr10) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
ATP1A1 Rabbit anti-Human Polyclonal (pSer23) Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
ATP1A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
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