ATG3

autophagy related 3

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

ATG3 (10)

Publications

No (10)

Tag

6His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His-SUMO (1)

Myc-DDK (Flag) (3)

T7, N-terminus + 6His, C-terminus (1)

Species

Human (9)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human ATG3 Protein (Recombinant His) - LS-G2931

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human ATG3 Protein (Recombinant GST) (Full Length) - LS-G34992

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ATG3 Protein (Recombinant T7, N-terminus + 6His, C-terminus) (Met1-Met314) - LS-G39558

Source:

E. coli

Tag:

T7, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36kD

Price:

10 µg/$233; 50 µg/$269; 500 µg/$468; 1 mg/$603

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Human ATG3 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G63096

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ATG3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86845

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$150

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Human ATG3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70346

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

20 µg/$1,107

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ATG3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110247

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.7 kDa

Price:

100 µg/$494

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Human ATG3 Protein (Recombinant 6His, C-terminus) (Met1-Met314) - LS-G138684

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36 kDa

Price:

10 µg/$322; 50 µg/$358

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Human ATG3 Protein (Recombinant His-SUMO) (Full Length) - LS-G20507

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

51.8 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ATG3 Protein (Recombinant His) (aa1-337) - LS-G3973

Source:

E. coli

Tag:

His

Molecular Weight:

~37kDa (SDS-PAGE)

Price:

50 µg/$274

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