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ATF7IP / MCAF1
activating transcription factor 7 interacting protein
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
| Gene Name: | activating transcription factor 7 interacting protein |
| Synonyms: | ATF7IP, ATF-interacting protein, AM, ATF7-interacting protein, ATF-IP, MCAF1, p621, ATFa-associated modulator, HAM, MCAF |
| Target Sequences: | NM_018179 NP_060649.3 Q6VMQ6 |
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