ATF6

activating transcription factor 6

ATF6 is a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

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Proteins (4)

Type

Recombinant (4)

Target

ATF6 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Species

Human (3)

Mouse (1)

Source

E. coli (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ATF6 Protein (Recombinant His-T7) (aa423-646) - LS-G13760

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.7 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human ATF6 Protein (Recombinant GST) (Full Length) - LS-G32677

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ATF6 Protein (Recombinant GST, N-terminus) (aa91-193) - LS-G61877

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse ATF6 Protein (Recombinant His-T7) (aa1-377) - LS-G24306

Source:

E. coli

Tag:

His-T7

Molecular Weight:

44.6 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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