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ATAD5 / ELG1
ATPase family, AAA domain containing 5
Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.
| Gene Name: | ATPase family, AAA domain containing 5 |
| Synonyms: | ATAD5, C17orf41, FRAG1, ELG1 |
| Target Sequences: | NM_024857 NP_079133.3 Q96QE3 |
Publications (1)
1
Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Michelle L Wegscheid, Corina Anastasaki, Kelly A Hartigan, Olivia M Cobb, Jason B Papke, Jennifer N Traber, Stephanie M Morris, David H Gutmann. Cell reports. 2021 July;36:109315. [Full Text Article]
[PubMed:34233200]
[PMC:PMC8278229]
Related Antibodies: LS-C19118.
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Products
Antibodies
(6)
Type
Primary
(6)
Target
ATAD5 / ELG1
(6)
Reactivity
Human
(5)
Mouse
(1)
Application
WB
(4)
ELISA
(3)
IP
(1)
Peptide-ELISA
(2)
Host
rabbit
(4)
goat
(2)
Isotype
IgG
(4)
Clonality
polyclonal pc
(6)
Format
Unconjugated
(6)
Epitope
aa1436-1450
(1)
aa1537-1548
(1)
aa775-825
(1)
Publications
No
(5)
Yes
(1)
![ATAD5 / ELG1 Antibody - Anti-Elg1 Antibody - Western Blot. Western blot of Affinity Purified anti-Elg1 antibody shows detection of a band ~120 kD corresponding to human Elg1 (arrowhead) in various cell lysates. Lanes contain ~5 ug of HeLa nuclear extract (1), HeLa (2), A431 (3), Jurkat (4) and HEK293 (5) whole cell lysates. After SDS-PAGE, transfer and blocking, the membrane was probed with the primary antibody diluted to 1:500. The membrane was then washed and reacted with a HRP conjugated Gt-a-Rabbit IgG [H&L] MX followed by ECL detection using a 2 m exposure time. The expected molecular weight of Elg1 is 120kD according to Kanellis P et al. 2003, although the predicted molecular weight is 207 kD. The 50kD bands in Jurkat and 293 cell lysates are probably cross-reaction with other proteins. Both the 120 kD and 50 kD bands are not observed when antibody is pre-incubated with peptide (data not shown).](https://lsbio-7d62.kxcdn.com/image2/atad5-elg1-antibody-ls-c19118/62871_5139653.jpg)
ATAD5 / ELG1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$567
ATAD5 / ELG1 Rabbit anti-Human Polyclonal (aa775-825) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ATAD5 / ELG1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
ATAD5 / ELG1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ATAD5 / ELG1 Goat anti-Mouse Polyclonal (aa1537-1548) Antibody
Mouse
Peptide-ELISA
Unconjugated
100 µg/$401
ATAD5 / ELG1 Goat anti-Human Polyclonal (aa1436-1450) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$503
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