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May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
Gene Name: | ATPase Family, AAA Domain Containing 2 |
Synonyms: | ATAD2, PRO2000, ANCCA |
Target Sequences: | NM_014109 NP_054828.2 Q6PL18 |
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