ASPN / Asporin

asporin

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

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Products

Proteins (3)

Type

Recombinant (3)

Target

ASPN / Asporin (3)

Publications

No (3)

Tag

6His-SUMO, N-terminus (1)

GST (1)

His-GST, N-terminus (1)

Species

Human (2)

Mouse (1)

Source

E. coli (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Mouse ASPN / Asporin Protein (Recombinant His-GST, N-terminus) (aa16-373) - LS-G24781

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

70.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ASPN / Asporin Protein (Recombinant 6His-SUMO, N-terminus) (aa33-380) - LS-G56102

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human ASPN / Asporin Protein (Recombinant GST) (Full Length) - LS-G34065

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.3 kDa

Price:

2 µg/$439

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