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ASIP
agouti signaling protein
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
| Gene Name: | agouti signaling protein |
| Synonyms: | ASIP, Agouti-signaling protein, AGTIL, Agouti signaling protein, AGTI, Agouti switch protein, AGSW, SHEP9, ASP, Nonagouti homolog |
| Target Sequences: | NM_001672 NP_001663.2 P42127 |
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