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ASIC1 / ACCN2
acid-sensing (proton-gated) ion channel 1
Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
| Gene Name: | acid-sensing (proton-gated) ion channel 1 |
| Family/Subfamily: | Ion Channel , Sodium channel - amiloride-sensitive |
| Synonyms: | ASIC1, Acid-sensing ion channel 1, ACCN2, Acid-sensing ion channel, ASIC1A, BNaC2, Brain sodium channel 2, HBNaC2, ASIC, ASIC1B |
| Target Sequences: | NM_020039 NP_064423.2 P78348 |
Publications (1)
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