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ASIC1 / ACCN2
acid-sensing (proton-gated) ion channel 1
Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
| Gene Name: | acid-sensing (proton-gated) ion channel 1 |
| Family/Subfamily: | Ion Channel , Sodium channel - amiloride-sensitive |
| Synonyms: | ASIC1, Acid-sensing ion channel 1, ACCN2, Acid-sensing ion channel, ASIC1A, BNaC2, Brain sodium channel 2, HBNaC2, ASIC, ASIC1B |
| Target Sequences: | NM_020039 NP_064423.2 P78348 |
Publications (1)
1
Regulation of acid-sensing ion channel 1a function by tissue kallikrein may be through channel cleavage. Jingjing Su, Yuping Tang, Ling Liu, Houguang Zhou, Qiang Dong. Neuroscience letters. 2011 490:46-51. (WB; Human, Hamster)
[Full Text Article]
[PubMed:21167908]
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ASIC1 / ACCN2 Rabbit anti-Rat Polyclonal (aa100-150) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
Unconjugated
100 µg/$665
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal (aa500-526) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
ASIC1 / ACCN2 Goat anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
Unconjugated
100 µg/$442
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (Biotin) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
Biotin Conjugated
100 µg/$475
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (FITC) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
FITC Conjugated
100 µg/$472
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (PerCP) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
PerCP Conjugated
100 µg/$478
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (RPE) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
RPE Conjugated
100 µg/$477
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (Atto 488) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
Atto 488 Conjugated
100 µg/$479
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (Atto 390) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
Atto 390 Conjugated
100 µg/$479
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (Atto 594) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
Atto 594 Conjugated
100 µg/$479
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (aa460-526) (APC) (S271-44) Antibody
Mouse, Rat
ICC, IHC, WB
APC Conjugated
100 µg/$478
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ASIC1 / ACCN2 Mouse anti-Mouse Monoclonal (S271-44) Antibody
Mouse, Rat
WB
Unconjugated
100 µg/$537
ASIC1 / ACCN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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