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ASCL1 / MASH1

achaete-scute family bHLH transcription factor 1

ACSL1 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.

Gene Name: achaete-scute family bHLH transcription factor 1
Synonyms: ASCL1, Achaete-scute homolog 1, ASH-1, BHLHa46, Achaete scute protein, Achaete-scute complex-like 1, HASH1, MASH1, ASH1
Target Sequences: NM_004316 NP_004307.2 P50553

Publications (1)

1
Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer. McColl K, Wildey G, Sakre N, Lipka MB, Behtaj M, Kresak A, Chen Y, Yang M, Velcheti V, Fu P, Dowlati A. Oncotarget. 2017 August;8:73745-73756. (Human) [Full Text Article] [PubMed:29088741] [PMC:PMC5650296] Related Antibodies: LS-C177728.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ASCL1 / MASH1 (7)
No (7)
GST (1)
GST, N-terminus (2)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (1)
ASCL1 / MASH1 Protein - Recombinant  Achaete Scute Complex Like Protein 1 By SDS-PAGE
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E. coli
His-T7
20.9 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
ASCL1 / MASH1 Protein - Purified recombinant protein ASCL1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
25.3 kDa
20 µg/$1,107
ASCL1 / MASH1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ASCL1 / MASH1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ASCL1 / MASH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
25.3 kDa
100 µg/$494
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293T Cells
Myc-DDK (Flag)
25.3 kDa
20 µg/$150
ASCL1 / MASH1 Protein - 12.5% SDS-PAGE of human ASCL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
51.9 kDa
2 µg/$439
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).