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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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ASCL1 / MASH1
achaete-scute family bHLH transcription factor 1
ACSL1 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.
| Gene Name: | achaete-scute family bHLH transcription factor 1 |
| Synonyms: | ASCL1, Achaete-scute homolog 1, ASH-1, BHLHa46, Achaete scute protein, Achaete-scute complex-like 1, HASH1, MASH1, ASH1 |
| Target Sequences: | NM_004316 NP_004307.2 P50553 |
Publications (1)
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