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ASB7
ankyrin repeat and SOCS box containing 7
ASB7 belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described.
| Gene Name: | ankyrin repeat and SOCS box containing 7 |
| Synonyms: | ASB7, ASB-7 |
| Target Sequences: | NM_024708 NP_078984.2 Q9H672 |
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