ASAP2 / DDEF2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

ASAP2 / DDEF2 is a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

ASAP2 / DDEF2 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ASAP2 / DDEF2 Protein (Recombinant GST) (Full Length) - LS-G31366

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

138.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ASAP2 / DDEF2 Protein (Recombinant GST, N-terminus) (aa909-1006) - LS-G60901

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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ASAP2 / DDEF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117027

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.5 kDa

Price:

100 µg/$710

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Human ASAP2 / DDEF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79855

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.5 kDa

Price:

20 µg/$215

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