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ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
| Gene Name: | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
| Synonyms: | ASAP1, AMAP1, Centaurin, beta 4, CENTB4, DEF-1, DDEF1, KIAA1249, PAP, PIP2-dependent ARF1 GAP, PAG2, ZG14P |
| Target Sequences: | NM_018482 NP_060952.2 Q9ULH1 |
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