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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.
| Gene Name: | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| Synonyms: | ASAH2, BCDase, Acylsphingosine deacylase 2, HCD, Mitochondrial ceramidase, NCDase, Non-lysosomal ceramidase, LCDase, N-CDase, Neutral ceramidase, HNAC1, Neutral/alkaline ceramidase |
| Target Sequences: | NM_019893 NP_063946.2 Q9NR71 |
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