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ARTS1 / ERAP1

endoplasmic reticulum aminopeptidase 1

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Gene Name: endoplasmic reticulum aminopeptidase 1
Family/Subfamily: Exopeptidase , Metallopeptidase M1
Synonyms: ERAP1, A-LAP, ALAP, APPILS, ARTS1, ERAAP, ERAAP1, KIAA0525, PILS-AP, Aminopeptidase PILS, ARTS-1, PILSAP
Target Sequences: AF106037 NP_057526.3 Q9NZ08

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Products
Antibodies (26)
Primary (26)
ARTS1 / ERAP1 (26)
Human (26)
Mouse (9)
Rat (7)
Hamster (1)
Monkey (1)
IHC (10)
IHC-P (7)
WB (18)
ELISA (11)
ICC (1)
IF (6)
IP (2)
Peptide-ELISA (3)
rabbit (20)
mouse (6)
Product Group
IHCPlus (4)
IgG (12)
IgG1,k (6)
monoclonal mc (6)
polyclonal pc (20)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (18)
Internal (4)
410-490 aa, Internal (1)
C-Terminus (1)
Lys467 (1)
aa418-467 (1)
aa441-490 (1)
aa451-480 (1)
aa832-942 (1)
No (26)
ARTS1 / ERAP1 Antibody - Anti-ERAP1 / ARTS1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (Internal) Antibody
Hamster, Human
IHC, IHC-P
Unconjugated
50 µg/$460
ARTS1 / ERAP1 Antibody - Anti-ERAP1 / ARTS1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
ARTS1 / ERAP1 Antibody - Immunohistochemical analysis of ERAP1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
ARTS1 / ERAP1 Antibody - Immunohistochemistry of ERAP1 in mouse brain tissue with ERAP1 antibody at 5 ug/ml.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
ARTS1 / ERAP1 Antibody - Anti-ERAP1 / ARTS1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
ARTS1 / ERAP1 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ARTS1 / ERAP1 Antibody - Immunohistochemistry image of paraffin-embedded human endometrial cancer at a dilution of 1:100
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
ARTS1 / ERAP1 Antibody - Western blot of ERAP1 antibody
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (410-490 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ARTS1 / ERAP1 Antibody - IHC of ERAP1 (K467) pAb in paraffin-embedded human breast carcinoma tissue.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (Lys467) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
ARTS1 / ERAP1 Antibody - Anti-ERAP1 / ARTS1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
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ARTS1 / ERAP1 Mouse anti-Human Monoclonal (aa832-942) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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ARTS1 / ERAP1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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ARTS1 / ERAP1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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ARTS1 / ERAP1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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ARTS1 / ERAP1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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ARTS1 / ERAP1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
ARTS1 / ERAP1 Antibody - Western blot analysis of extracts from HepG2 cells, Jurkat cells and HUVEC cells, using ARTS-1 antibody.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
ARTS1 / ERAP1 Antibody - Western blot analysis of lysates from HepG2, Jurkat, and HUVEC cells, using ARTS-1 Antibody. The lane on the right is blocked with the synthesized peptide.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (aa441-490) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ARTS1 / ERAP1 Antibody - Western blot analysis of the lysates from HepG2 cells using ARTS-1 antibody.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (aa418-467) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ARTS1 / ERAP1 Antibody - Western blot of anti-ARTS1 Antibody in Ramos cell line lysates (35 ug/lane). ARTS1 (arrow) was detected using the purified antibody.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal (aa451-480) Antibody
Human
WB
Unconjugated
400 µl/$393
ARTS1 / ERAP1 Antibody - Western blot analysis of extracts of various cell lines.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
ARTS1 / ERAP1 Antibody - Anti-ERAP1 Antibody at 1:1000 dilution + K562 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 107 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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ARTS1 / ERAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$386
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).