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ART4 encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
Gene Name: | ADP-ribosyltransferase 4 (Dombrock blood group) |
Synonyms: | ART4, ADP-ribosyltransferase 4, ARTC4, CD297 antigen, DO, Mono-ADP-ribosyltransferase 4, CD297, Dombrock blood group, Ecto-ADP-ribosyltransferase 4, Mono(ADP-ribosyl)transferase 4 |
Target Sequences: | NM_021071 NP_066549.2 Q93070 |
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