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ARRB2 / Beta Arrestin 2

arrestin, beta 2

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: arrestin, beta 2
Synonyms: ARRB2, Arrestin 3, Arrestin beta-2, ARB2, ARR2, BARR2, Arrestin, beta 2, Beta-arrestin-2
Target Sequences: NM_004313 NP_004304.1 P32121

Publications (4)

1
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V. Immunobiology. 2011 216:854-61. [PubMed:21193245] Related Antibodies: LS-C54486.
2
Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of ß-arrestin2. Deborah J Luessen, Haiguo Sun, Molly M McGinnis, Michael Hagstrom, Glen Marrs, Brian A McCool, Rong Chen. The Journal of biological chemistry. 2019 September;294:14068-14080. [Full Text Article] [PubMed:31366729] [PMC:PMC6755807] Related Antibodies: LS-B6008.
3
Pioglitazone Enhances ß-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues. Shaimaa El-Fayoumi, Rehab Mansour, Amr Mahmoud, Ahmed Fahmy, Islam Ibrahim. Pharmacology. 2021 June;106:409-417. [Full Text Article] [PubMed:34082428]
4
Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia. Napolitano F, Pasqualetti M, Usiello A, Santini E, Pacini G, Sciamanna G, Errico F, Tassone A, Di Dato V, Martella G, Cuomo D, Fisone G, Bernardi G, Mandolesi G, Mercuri NB, Standaert DG, Pisani A. Neurobiology of disease. 2010 38:434-45. [PubMed:20227500] Related Antibodies: LS-C54486.
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ARRB2 / Beta Arrestin 2 (7)
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ARRB2 / Beta Arrestin 2 Protein - Recombinant Arrestin Beta 2 By SDS-PAGE
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E. coli
His-GST
45.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
ARRB2 / Beta Arrestin 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ARRB2 / Beta Arrestin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44.2 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
44.2 kDa
20 µg/$150
ARRB2 / Beta Arrestin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.2 kDa
100 µg/$494
ARRB2 / Beta Arrestin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.2 kDa
100 µg/$494
ARRB2 / Beta Arrestin 2 Protein - 12.5% SDS-PAGE of human ARRB2 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.5 kDa
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).