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ARPIN / C15orf38
chromosome 15 open reading frame 38
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
| Gene Name: | chromosome 15 open reading frame 38 |
| Synonyms: | ARPIN, C15orf38, UPF0552 protein C15orf38 |
| Target Sequences: | NP_872422.1 Q7Z6K5 |
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