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ARPC4 is one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein.
Gene Name: | actin related protein 2/3 complex, subunit 4, 20kDa |
Synonyms: | ARPC4, Arp2/3 complex 20 kDa subunit, ARC20, p20-ARC |
Target Sequences: | NM_005718 NP_005709.1 P59998 |
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