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ARNTL / BMAL1

aryl hydrocarbon receptor nuclear translocator-like

ARNTL / BMAL1 is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: aryl hydrocarbon receptor nuclear translocator-like
Synonyms: ARNTL, BHLH-PAS protein JAP3, BHLHe5, BMAL1c, JAP3, PASD3, Member of PAS protein 3, MOP3, TIC, Brain and muscle ARNT-like 1, Member of PAS superfamily 3
Target Sequences: NM_001178 NP_001169.3 O00327

Publications (5)

1
Proxisome proliferator-activated receptor- mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice. Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S. Chronobiology international. 2010 27:1735-53. (WB, ChrIP; Mouse) [PubMed:20969520]
2
Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src. Lauzier A, Charbonneau M, Harper K, Jilaveanu-Pelmus M, Dubois CM. Arthritis and rheumatism. 2011 63:1591-602. (ICC; Rat) [PubMed:21337539]
3
Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver. Ribas-Latre A, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Bladé C, Arola L. Scientific reports. 2015 5:10954. (WB; Human) [Full Text Article] [PubMed:26051626] [PMC:PMC4603780] Related Antibodies: LS-C16603.
4
Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes. Litlekalsoy J, Rostad K, Kalland KH, Hostmark JG, Laerum OD. BMC cancer. 2016 16:549. (WB, IHC-P; Mouse, Human) [Full Text Article] [PubMed:27465361] [PMC:PMC4964027]
5
Core circadian clock transcription factor BMAL1 regulates mammary epithelial cell growth, differentiation, and milk component synthesis. Theresa Casey, Aridany Suarez-Trujillo, Shelby Cummings, Katelyn Huff, Jennifer Crodian, Ketaki Bhide, Clare Aduwari, Kelsey Teeple, Avi Shamay, Sameer J Mabjeesh, Phillip San Miguel, Jyothi Thimmapuram, Karen Plaut. PloS one. 2021 August;16:e0248199. [Full Text Article] [PubMed:34415905] [PMC:PMC8378744]
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ARNTL / BMAL1 (4)
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96-Well Strip Plate (4)
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ARNTL / BMAL1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$783
ARNTL / BMAL1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
ARNTL / BMAL1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
ARNTL / BMAL1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).