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Arkadia / RNF111

ring finger protein 111

Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.

Gene Name:	ring finger protein 111
Synonyms:	RNF111, Arkadia, ARK, Ring finger protein 111, DKFZP761D081
Target Sequences:	NM_017610 NP_060080.6 Q6ZNA4

Arkadia / RNF111 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.

Human Arkadia / RNF111 Protein (Recombinant GST, N-terminus) (aa1-108) - LS-G62619

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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