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E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.
Gene Name: | ariadne RBR E3 ubiquitin protein ligase 1 |
Synonyms: | ARIH1, ARI, HARI, Monocyte protein 6, MOP-6, Protein ariadne-1 homolog, UbcH7-binding protein, ARI-1, UbcM4-interacting protein, H7-AP2, HHARI, MOP6, UBCH7BP |
Target Sequences: | NM_005744 NP_005735.2 Q9Y4X5 |
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